Drugs are chemicals or biological compounds that have a physiological or biological effect on our bodies to heal the disease and maintain better health. The development of a new drug is a complex and expensive process that resides in many types of research. Drug Design and discovery is the inventive research of inventing new medications, which is most commonly an organic small molecule that activates the function of a biomolecule like protein, that will turn healing benefit to the target as a patient. In the pharmaceutical research companies to take the path from diagnosing the disease to bringing a safe and effective new treatment to patients. It takes around 10-15 years to create one new prescription from the time it is found to when it is accessible for treating patients. The discovery process includes all early research to identify a new drug and testing in the lab. Before the end, analysts want to have a promising applicant Drug to test in individuals.

Sub-Tracks

·        Basic Principles in Drug Design and Development.

·        Molecular Recognition in Drug Design.

·        Stereochemistry in drug design 

·        Receptors: structure, function and pharmacology 

·        Excitatory and inhibitory amino acid receptor ligands 

 ·        Peptides and peptidomimetics 

Medicinal Chemistry manages the plan, advancement and improvement of concoction mixes for use as Drugs. It is characteristically a multidisciplinary subject starting with the amalgamation of potential Drugs pursued by examines exploring their connections with natural focuses to comprehend the restorative impacts of the Drugs, its metabolism and reactions. Medicinal chemists are indispensable in the preclinical stages of drug development, and again as pharmaceutical chemists in drug quality control. The section depicts phases of Drug Development, trailed by a synopsis of the periods of Drug activity identifying with a Drug formulation, pharmacokinetics and pharmacodynamics. Finally, the classification systems for marketed drug substances are presented, with an emphasis on the classification by the molecular target.

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·         Chemical Intuition in Drug Design and Discovery

·        Strategies and Tactics in Medicinal Chemistry

·        Molecular Hybridization

·        Multitarget Drug 

·        Conformational Restriction 

·        Homologation

·        Virtual Screening Techniques

·        Allosteric Metabotropic Glutamate Receptor (mGluR) Modulators

Poor delivery characteristics of potential drug candidates are efficiently overcome by the exploitation of bio reversible chemical derivatization or in other words the prodrug approach. Prodrugs are inert or less dynamic subsidiaries of Drug Molecules that experience substance or enzymatic change in vivo to discharge the dynamic Drug moiety answerable for inspiring pharmacological impacts. Prodrug design comprises an area of drug research devoted to the optimization of drug delivery where the pharmacologically inactive prodrug requires transformation within the body in order to release the active drug. This approach has many advantages. First, the changes in physicochemical properties and the pharmacological profile of the drug are transient since the well-characterized parent drug molecule is regenerated from the prodrug. Second, the introduction of several chemical transient changes in the drug molecule is possible allowing prodrug derivatives with a broad spectrum of physicochemical properties to be synthesized. Prodrug undergoes quantitative chemical or enzymatic conversion to the parent compound (and a nontoxic transport-moiety). Prodrug formation can thus be considered as a means to mask temporarily undesirable physicochemical properties of the parent molecule. 

 Sub-Tracks

·           Enzymatic hydrolysis of Prodrugs

·           Nalmefene prodrugs

·           Strategies for Paclitaxel.

·           Troxacitabine prodrugs

·           Amino acids as promote ties in prodrug

·           Prodrugs for Gene-Directed Enzyme-Prodrug treatment

·           Lipid prodrug nanocarriers in cancer treatment

·           Analgesic Prodrugs for Combating their Side-Effects

·           Effect of Simvastatin Prodrug macromolecular prodrug

The growth in Artificial intelligence (AI) have successfully applied to the many areas like as Natural Language Processing, Voice recognition. Now AI is widely applied into life science field like biology, chemistry and so on. An AI is commonly used for improving success rates and lower the cost of drug discovery and drug development. The Research Topic covers new AI algorithms in a wide range of areas such as drug target identification, pharmacogenomics, network pharmacology, chemical property prediction, synthesis planning, molecular design and generation, protein-ligand interaction, drug-target interaction network, big-data analysis for drug information, and image recognition. 

Sub-Tracks

·        Artificial Intelligence

·        Planning Chemical Syntheses

·        Virtual Screening

·       Artificial Neural Networks

·        Big Data

·        Deep Learning

·        Drug Discovery

Sub Tracks

·        Site Identification by Ligand Competitive Saturation (SILCS)

·        Database Preparation

·        Docking

·        Single-step Free Energy Perturbation

·        QSAR/QSPR

·        Predictive toxicology

Sub Tracks:

• Reversible Modes of Inhibitor Interactions with Enzymes.
• Assay Considerations for Compound Library Screening.
• Slow/Tight Binding Inhibitors.
• Irreversible Enzyme In activators.

Antiviral agents are commonly used to give production of viruses that cause disease. It is very difficult to find medicines of the host cell. In any case, a few enzymes are just present in infections and these are potential focuses for antiviral Drugs. Agents that inhibit the transcription of the viral genome are DNA polymerase inhibitors and reverse transcriptase inhibitors. Protease inhibitors inhibit post-translational events. Other antiviral operators restrain the infection from appending to or infiltrating the host cell. Immunomodulators incite generation of host cell enzymes, which stop viral multiplication. Integrase strand move inhibitors anticipate a mix of the viral DNA into the host DNA by repressing the viral enzyme integrase. Neuraminidase inhibitors block viral enzymes and inhibit reproduction of the viruses.

Anti-Cancer agent in drug chemistry aims to cover all the latest and outstanding developments in drug chemistry and rational drug design for the discovery of anti-cancer agents. The most serious issue in anticancer drug development is gaining multidrug opposition and backslide. Classical chemotherapeutics directly targeting the proteins processing abnormal expression inside the cancer cells. Conventional strategies for the complete eradication of the cancer cells proved ineffective. Directed chemotherapy was fruitful in specific malignancies in any case, the viability has frequently been constrained by drug resistance and symptoms on typical tissues and cells. Since the most recent couple of years, many promising Drug targets have been distinguished for the powerful treatment of disease.

 Sub Tracks:

·        Anti-Cancer Agents from Plants

·        Clinical Pharmacology of Anti-Cancer Agents

·        Natural Sources of Anti-Cancer Agents

·        Mechanism of Drug Sensitivity and Resistance 

Nanomedicine is a part of medication that applies the information and devices of nanotechnology to the aversion and treatment of disease. Nanomedicine includes the utilization of nanoscale materials, for example, biocompatible nanoparticles and nanorobots, for diagnosis, conveyance, detecting or activation purposes in a living being. Like for any leap forward innovation, the promising potential outcomes that nanomedicine offer later must be counterweighted against dangers. The wellbeing of nanomedicine, items are managed precisely like medications and medicinal gadgets, clinically assessed for their advantage/hazard proportion for the patients. As any Medical Devices or Drugs, nanomedicines are carefully controlled and need to pursue exhaustively portrayal, lethality appraisal and multi-organize clinical preliminaries assessing for their advantage/hazard proportion before profiting patients with their entire potential.

 Sub-Tracks

• Artificial Cell
• Surface-Mediated Drug Delivery
• Nanoparticles
• Nanotechnology
• Medical Devices
• Nanomedicine 

Drug from Natural Products and traditional medicines are vital. Natural products and their subordinates have been perceived for a long time as a wellspring of remedial specialists and basic decent variety. Regular items have a wide scope of assorted variety of multidimensional substance structures; meanwhile, the utility of characteristic items as organic work modifiers has additionally won impressive consideration.  Drug Discovery is prompting be a provoking logical errand to discover vigorous and feasible lead competitors, which is only the procedure stream from a screening of common item to another disconnect that requires skill and experience. Be that as it may, notwithstanding their concoction structure assorted variety and their biodiversity, the improvement of new innovations has reformed the screening of natural products in finding new Drugs.

 Sub-Tracks

• Herbal Drug Discovery
• Natural Product Drugs
• Microbial Diversity
• Natural Product Inhibitors
• Natural Product for Anti-Cancer Therapy
• Biosynthesis

Targeted drug delivery (TDD) is developing as a useful asset for the treatment of cancer due to upgraded delivery of drugs, just as qualities, to a tumour site with the assurance from the extracellular condition. Stimuli-responsive NanoGels (NGs) are a three-dimensional hydrophilic polymer networks that are formed via covalent linkages or self-assembly processes and can change their structural properties in the presence of external stimuli. These NGs have been widely examined as smart drug delivery carriers for a variety of anticancer drugs, as well as genes, because of stability, ease of synthesis, good control over particle size, and easy functionalization. Targeted drug delivery is a strategy that selectively and preferentially delivers the therapeutic agents to the target site concurrently failing access to the nontarget site. For this purpose, one of the attractive strategies is the use of “ligand” that will facilitate the homing of the therapeutic moieties to the target tissues. Ligand-targeted chemotherapeutics are based on the exploitation of antigens or receptors that are either inimitably expressed or overexpressed on the tumour cells compared to normal tissues in order to protect normal tissues from the reach of anticancer drugs and to deliver the anticancer drug selectively to tumour tissue. 

Drug repositioning or Drug repurposing is a way to deal with quicken the Drug Discovery process through the distinguishing proof of a novel clinical use for a current medication endorsed for an alternate sign. The expanded achievement and uses of Drug repurposing can be considered as one of the results of poly pharmacology and it speaks to a sign of the move from a solitary to multitarget worldview in Drug Discovery. 

 Drug Repurposing can lessen social insurance costs, given how relentless, tedious, and expensive again sedate revelation ventures have been. Drug-candidate molecules that have been appeared as being protected, yet inadequately successful for the planned objective, can be considered for different targets, thus perhaps diminishing the expenses of clinical preliminary. The expanding sum and accessibility of open and open source databases, information, calculations, and servers have empowered more members of Drug repurposing ventures. 

 Sub Tracks

·        Basis of Drug Repurposing

·        Poly Pharmacology

·        Computer-Assisted Drug Repurposing

·        Holistic Drug Targeting

In this Drug Design, 2020 Conference covers the hypothetical foundation and philosophies of valuable procedures of cheminformatics and bioinformatics that can be applied for Drug repurposing. Our Congress is aiming to Offers deep discussions on contextual investigations identifying with the in silico demonstrating of FDA-affirmed drugs for the revelation of antifungal, anticancer, antiplatelet specialists, and for medicating treatments against sicknesses. In-silico medicate structure aptitudes are utilized in nanotechnology, molecular biology, biochemistry and so forth.

Sub Tracks 

• Homology modelling
• Molecular docking
• Virtual high-throughput screening
• Quantitative structure-activity relationship (QSAR)
• Hologram quantitative structure-activity relationship (HQSAR)
• Comparative molecular field analysis (CoMFA)
• Microarray analysis
• Conformational analysis
• Molecular dynamic (MD) simulation

Anti-infection opposition is a significant danger to worldwide wellbeing and specialists have attempted to distinguish new antimicrobial mixes. Most anti-infection agents are gotten from little molecule created by microscopic organisms, and the qualities that orchestrate, direct, and send out these particles ordinarily happen together in bunches called biosynthetic quality groups, which run in size from only a bunch to a few dozen qualities. Sequencing endeavours have uncovered that the genomes of anti-microbial delivering life forms, for example, Streptomyces coelicolor, contained an enormous number of quality bunches that were "quiet" or "secretive" and were not communicated under research centre conditions. Bioinformatic instruments would now be able to distinguish numerous quiet biosynthetic quality bunches in bacterial genomes. The subsequent stage is making sense of how to actuate them. "That would significantly change normal item revelation and furthermore sedate disclosure" says Seyedsayamdost. Scientists have attempted numerous methodologies, for example, communicating these quality groups in other bacterial species, adjusting their advertisers or controllers and changing how the microscopic organisms are refined.

Sub-Tracks

• Antibiotic Resistance
• Antibiotics
• Bioinformatics
• Genetics & Genomics 
• Microbiology
• Silent Gene Clusters
• Synthetic Biology Techniques

The Drug Development model today is under expanding pressure as the number of medications endorsed for showcasing has dwindled to a record-breaking low. Drug Developers must recognize this pattern before starting the improvement procedure. In any case, for a creating biotechnology or pharmaceutical organization, where assets are generally constrained, it is basic to have a flat out a valuation for the business patterns.

Drug Development is a protracted, complex, and expensive procedure, settled in with a high level of vulnerability that a Drug will really succeed. The obscure pathophysiology for some, sensory system issue makes target recognizable proof testing. Creature models regularly can't summarize a whole disorder or disease. Provokes identified with the heterogeneity of the patient populace may be mitigated with expanded clinical phenotyping and genotyping. More noteworthy accentuation on human information may prompt improved target ID and approval. There is an absence of approved diagnostic and restorative biomarkers to dispassionately distinguish and gauge natural states. Newness to current administrative procedures for an investigational new drug (IND) applications can be settled through pre-IND gatherings.

 Sub-Tracks

• Current Drug Development Challenges
• Unknown Biological Mechanisms and Biomarkers of Diseases
• Translational Failures Using Animal Models
• Pipeline Challenges
• The Regulatory Process
• Guidance and Clarification for IND Application