Targeted drug delivery (TDD) is developing as a useful asset for the treatment of cancer due to upgraded delivery of drugs, just as qualities, to a tumour site with the assurance from the extracellular condition. Stimuli-responsive NanoGels (NGs) are a three-dimensional hydrophilic polymer networks that are formed via covalent linkages or self-assembly processes and can change their structural properties in the presence of external stimuli. These NGs have been widely examined as smart drug delivery carriers for a variety of anticancer drugs, as well as genes, because of stability, ease of synthesis, good control over particle size, and easy functionalization. Targeted drug delivery is a strategy that selectively and preferentially delivers the therapeutic agents to the target site concurrently failing access to the nontarget site. For this purpose, one of the attractive strategies is the use of “ligand” that will facilitate the homing of the therapeutic moieties to the target tissues. Ligand-targeted chemotherapeutics are based on the exploitation of antigens or receptors that are either inimitably expressed or overexpressed on the tumour cells compared to normal tissues in order to protect normal tissues from the reach of anticancer drugs and to deliver the anticancer drug selectively to tumour tissue.
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